Adenosine A3 Receptor anticorps (Extracellular)

N° du produit ABIN7237577

Cet anticorps anti-Adenosine A3 Receptor est un anticorps Lapin Polyclonal détectant Adenosine A3 Receptor dans WB, FACS et LCI. Adapté pour Souris.

Aperçu rapide pour Adenosine A3 Receptor anticorps (Extracellular) (ABIN7237577)

Antigène: Adenosine A3 Receptor (ADORA3)

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Adenosine A3 Receptor est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-Adenosine A3 Receptor anticorps

Épitope: AA 149-161, Extracellular

Fonction: A Rabbit Polyclonal antibody to Adenosine A3 Receptor (extracellular)

Specificité: Extracellular, 2nd loop.

Réactivité croisée: Souris, Rat

Réactivité croisée (Details): The antibody will not recognize adenosine A3 receptor from human samples.

Homologie: Rat - 10 out of 13 amino acid residues identical

Attributs du produit: Extracellular, 2nd loop

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)GWNRKATLASSQN, corresponding to amino acid residues 149 - 161 of mouse ADORA3

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:200

Commentaires:

Negative Control: (ABIN7234643)

Blocking Peptide: (ABIN7234643)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur Adenosine A3 Receptor

Antigène: Adenosine A3 Receptor (ADORA3)

Autre désignation: ADORA3

Sujet: ADORA3, A3AR, Adenosine Receptor A3,Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including the brain and heart.1,2 Adenosine exerts its action via four specific adenosine receptors (also named P1 purinergic receptors): Adenosine A1 Receptor (A1AR), Adenosine A2A Receptor (A2AAR), Adenosine A2B Receptor (A2BAR), and Adenosine A3 Receptor (A3AR). The various adenosine receptors can be distinguished on the basis of their distinct molecular structures, distinct tissue distributions, and differential selectivity for adenosine analogs.1-4 All are integral membrane proteins and are members of the G protein-coupled receptor superfamily. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, a cytoplasmic carboxyl terminus, and a third intracellular loop important in binding G proteins.1-3Expression of A3AR has been reported in the brain, kidney, liver, and heart. It plays a role in modulation of cerebral ischemia, asthma, and cell growth. In addition, recent studies have established a cardioprotective role for A3AR.5 Expression of A3AR was reported to be elevated in cancerous tissues as well as in auto-immune inflammatory diseases.6,7 A patent has been filed for the use of A3AR and A3AR agonist as a diagnostic marker for therapeutic treatments of cancer and other diseases.ADORA3, A3AR, Adenosine Receptor A3

ID gène: 11542

UniProt: Q61618

Pathways: Hormone Transport, cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process